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[Molecular Biology] Yang-Ming University Research Team Discovers Macrobiotic Gene
Posted by gustav
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[Molecular Biology] Yang-Ming University Research Team Discovers Macrobiotic Gene
分類標籤: Sci-Tech Digest
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[Molecular Biology] Yang-Ming University Research Team Discovers Macrobiotic Gene (Chinese Version)
National Yang-Ming University Realtime News reports (2009/05/15), the significant center of American Molecular Biology Cold Spring Harbor Laboratory released the news at five o'clock (east US time) on 14th-May that in the May 15th issue of G&D, Genes & Development, Dr. Ting-Fen TSAI (The National Yang-Ming University, Taiwan) and colleagues present a new animal model of human Wolfram Syndrome, and effectively link CISD2 gene function, mitochondrial integrity and aging in mammals. The research is funded by NSC and Ministry of Education, and the team members are from National Health Research Institutes, Chang Gung University, Soochow University as well. The findings of the team reveal that the length of life of mammals (including human and mice) is conditioned by specific genes. The findings are featured as cover story of the May 15th issue of G&D.
Professor Ting-Fen TSAI, National Yang-Ming University, (the left in the picture above) discovers the role for CISD2 Gene in human disease and lifespan control. The researchers engineered CISD2-deficient knock-out mice, which, by four to eight weeks (about 15 to 25 years old in human), were observed an obvious premature-aging phenotype. Th findings proves that the performance of the CISD2 gene function indeed has impact on lifespan. As the normal mammals age, the performance of GISD2 gene gets poorer. Perhaps by increasing the performance of GISD2 gene function, e.g., by giving stimulus from specific anti-aging chemicals, life length may get increased in the future. Besides, through the experiments on the mutated mice, the team for the first time find the proof supporting that defects in recessive CISD2 gene, i.e., the CISD2 gene in both homologous chromosomes are broken, are the cause of Wolfram syndrome 2 (WFS2), for they make the mitochondria in disorder and then increase the process of aging. The research goal in the future of the team is set to understand the pathological mechanism of the WFS2 formation with the mutated mice model, and then to find the possible curing method.
Reference:
National Yang-Ming University Realtime News 2009/05/15
National Yang-Ming University Realtime News reports (2009/05/15), the significant center of American Molecular Biology Cold Spring Harbor Laboratory released the news at five o'clock (east US time) on 14th-May that in the May 15th issue of G&D, Genes & Development, Dr. Ting-Fen TSAI (The National Yang-Ming University, Taiwan) and colleagues present a new animal model of human Wolfram Syndrome, and effectively link CISD2 gene function, mitochondrial integrity and aging in mammals. The research is funded by NSC and Ministry of Education, and the team members are from National Health Research Institutes, Chang Gung University, Soochow University as well. The findings of the team reveal that the length of life of mammals (including human and mice) is conditioned by specific genes. The findings are featured as cover story of the May 15th issue of G&D.
The research team and the cover of G&D / National Yang-Ming University Realtime News
Professor Ting-Fen TSAI, National Yang-Ming University, (the left in the picture above) discovers the role for CISD2 Gene in human disease and lifespan control. The researchers engineered CISD2-deficient knock-out mice, which, by four to eight weeks (about 15 to 25 years old in human), were observed an obvious premature-aging phenotype. Th findings proves that the performance of the CISD2 gene function indeed has impact on lifespan. As the normal mammals age, the performance of GISD2 gene gets poorer. Perhaps by increasing the performance of GISD2 gene function, e.g., by giving stimulus from specific anti-aging chemicals, life length may get increased in the future. Besides, through the experiments on the mutated mice, the team for the first time find the proof supporting that defects in recessive CISD2 gene, i.e., the CISD2 gene in both homologous chromosomes are broken, are the cause of Wolfram syndrome 2 (WFS2), for they make the mitochondria in disorder and then increase the process of aging. The research goal in the future of the team is set to understand the pathological mechanism of the WFS2 formation with the mutated mice model, and then to find the possible curing method.
Reference:
National Yang-Ming University Realtime News 2009/05/15
Edited 2 time(s). Last edit at 05/16/2009 07:08PM by gustav.
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