[BioChemistry] Academia Sinica Biochemistry Researchers Discover Why Common Cataract Remedy Works

[BioChemistry] Academia Sinica Biochemistry Researchers Discover Why Common Cataract Remedy Works (Chinese Version)

Academia Sinica Newsletter (2011/02/16) A biochemical research team led by Professor Shih-Hsiung WU, Distinguished Research Fellow and Deputy Director of Institute of Biological Chemistry has explained the biochemical mechanism behind a type of eye drops commonly used for cataract. Previously, the reason why this eye drop solution was effective against cataract was unknown. The research was published in the online edition of Inorganic Chemistry, one of journals published by the American Chemical Society, on Dec. 7, 2010.

Eye drops containing a compound named pirenoxine (PRX) have been commonly used by cataract sufferers for nearly 60 years, and have a reputation for being very effective. Up until now, however, the biochemistry behind their effectiveness was unknown, and the legitimacy of their use has been questioned by doctors.

In their study, first author of the article, Dr. Jiahn-Haur LIAO, and his colleagues showed how PRX binds to calcium and selenite in the lens, effectively reducing the opacity seen in cataract. Abnormally high levels of calcium are known to result in the loss of transparency in the cortex of the lens. Selenite has also been connected to lens opacity in scientific studies.

In Taiwan pirenoxine-containing eye drops can only be purchased by prescription, but in several Asian countries they are available over-the-counter. The study may pave the way for the further use of pirenoxine as a bona fide treatment for cataract.


Media Contacts:
Professor Shih-Hsiung WU, Distinguished Research Fellow and Deputy Director of Institute of Biological Chemistry, Academia Sinica (Tel) 886-2-2789-9800 Ext. 8012
Mei-Hui LIN (Ms.), Public Affairs Office, Central Office of Administration, Academia Sinica (Tel) 886-2-2789-8821, (Fax) 886-2-2782-1551, (M) 0921-845-234 mhlin313@gate.sinica.edu.tw


Further Information:
Academia Sinica Newsletter 2011/02/16



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