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[生醫科技] 臺大團隊與中央研究院抗癌研究發現蝦白點症病毒新穎DNA擬態蛋白質毒殺細胞作用機制

[生醫科技] 臺大團隊與中央研究院抗癌研究發現蝦白點症病毒新穎DNA擬態蛋白質毒殺細胞作用機制

臺灣大學生命科學院院長羅竹芳與中央研究院副院長王惠鈞帶領臺大生化所和動物所博士班學生協力合作從結構生物學及細胞生物學探究蝦白點症病毒新穎蛋白質ICP11的功能。研究結果發現,由結構生物學的方法解出ICP11蛋白質是一種模仿DNA結構的蛋白質,由細胞生物學則進一步發現它可與宿主histone結合並瓦解宿主染色體。本研究同時也證實ICP11有加強核酸酶活性的功能。經由蝦白點症病毒ICP11的研究解開了病毒抗宿主的新穎策略,此為科學界的重要新發現。ICP11不僅具獨特的多功能性,並且在人類細胞中表現的 ICP11也可以導致細胞的計畫性死亡,因此它也極具潛力使用在高等生物如人類疾病的研究與應用上。本研究成果刊登在2008年12月30日《美國國家科學院期刑(Proceeding of the National Academy of Science of the United States of America; PNAS)》。


深入資訊:
臺大校訊953期

[Bionmedical] Research Team Formed of Taida and Aacademia Sinica Reaches Anti-Cancer Breakthrough, Finding the Cell-killing Mechanism of the New Mimic Protein in Shrimp White Spot Syndrome Virus

The Dean of NTU-College of Life Science Chu-Fang Lo and Academia Sinica's Vise-President Andrew H.-J. Wang lead a team of graduate students from NTU-Institute of Biochemical Sciences and Institute of Zoology, investigating the function of ICP11, a new mimic protein in shrimp white spot syndrome virus, from perspectives of structural biology and cell biology. The team finds that structural biological methods can prove CP11 to be one protein possessing mimic DNA structure, and that cell biological methods can prove ICP11 can be colocalized with its host histone and destroy the host's main chromosome. The investigation also proves that ICP 11 has the function of nuclease activation. The investigation of shrimp white spot syndrome virus ICP 11 suggests a new strategy of virus's opposing its host, which is a significant scientific finding. ICP11 not only possesses multiple functions but also can be applied to human cells resulting in their schemed death, which hence obtains rich potentials in the research and applications of higher organisms' diseases such as human's. The findings are presented in Proceeding of the National Academy of Science of the United States of America, PNAS, 30th-Dec., 2008.


Further Information:
National Taiwan University Newsletter Issue 953



Edited 1 time(s). Last edit at 03/03/2009 09:15PM by gustav.
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