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資訊來æºï¼š
ä¸ç ”院新èžç¨¿ 2009/04/22
[Medicine] Academia Sinica Presents Novel Drug Delivery Systems for Target Therapy of Cancer
A research team from the Institute of Cellular and Organismic Biology, Academia Sinica, led by Dr. Han-Chung WU has identified cancer-specific targeting ligands and developed novel peptide-mediated drug delivery systems for the treatment of cancer. This series of research projects has resulted in the filing of six patent applications, several of which have already been granted in Taiwan and the United States. Academia Sinica has licensed three patents to a biotechnology company for preclinical testing. The research team plans to finish preclinical studies and progress to clinical studies in the future.
Recently, the research team has identified several novel peptides that bind specifically to the plasma membrane of cancer cells as well as tumor-associated endothelial cells. In an effort to develop ligand-targeted therapy, research team used peptide-linked liposomes (targeting liposomes) that carried doxorubicin to treat severe combined immunodeficiency (SCID) mice bearing human tumor xenografts. These novel drug delivery systems were found to have enhanced anti-tumor effects and decreased side effects, while significantly increasing survival rates in mice bearing human lung cancer and liver cancer xenografts.
The lack of tumor specThe lack of tumor specificity remains a major drawback for effective chemotherapy regimes and results in dose-limiting toxicities. However, targeting drug delivery systems make possible tumor specificity with limited toxicity, and show promise for the development of novel therapies for cancer. The research team found that these treatment regimens could deliver sufficient amounts of a drug to targeted tumors while minimizing damage to normal tissues. Therefore, incomplete tumor response, early disease relapse, and drug resistance induced by conventional chemotherapeutic drugs could be reduced. At the same time, ongoing collaborative projects with Academia Sinica's Professor Alice Lin-Tsing YU at the Genomics Research Center and Professor John YU of the Institute of Cellular and Organismic Biology have been focusing on the study of in vivo imaging and optimization of targeting drug delivery systems. These results have been published in the prominent international journals, including
PLoS ONE,
Cancer Research, and
Molecular
Cancer Therapeutics.
Therapeutics.
Reference:
Academia Sinica Newsletter 2009/04/22